Comparative Study of Combination of Oral Tranexamic Acid With Modified Kligman’s Formula Versus Oral Tranexamic Acid With Azelaic Acid 15% in the Treatment of Melasma

Background Melasma is a persistent skin condition affecting individuals of Asian, African, and Hispanic backgrounds. It causes dark patches on sun-exposed areas the face. The exact are unclear, but UV light hormonal factors play role. significantly impacts physical appearance quality life, causing emotional social distress. Objective objective was to compare efficacy combination oral tranexamic acid modified Kligman’s formula vs. 15% azelaic acid. Material methods This two-year interventional study occurred at Outpatient Department Dermatology, Venereology, Leprosy in Sawangi, Maharashtra. included male female patients aged 18-50 with melasma seeking treatment. Ethical approval obtained, data collection involved medical histories, examinations, calculating Area Severity Index (MASI). Results found no significant association between age groups subject distribution Groups A B. Significant differences were observed MASI scores within each group over time. There difference mean Group B eight-week mark. burning sensation associated groups, while for erythema. Conclusion concludes that combining Kligman's more effective treating than 15%.